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The short answer: No.
The long answer: The reason why you ask this is because you probably heard or read somewhere that marijuana damages brain cells, or makes you stupid. These claims are untrue. [propaganda is what makes you stupid]
The first one — marijuana kills brain cells — is based on research done during the second Reefer Madness Movement. A study attempted to show that marijuana smoking damaged brain structures in monkeys. However, the study was poorly performed and it was severely criticized by a medical review board. Studies done afterwards failed to show any brain damage, in fact a very recent study on Rhesus monkeys used technology so sensitive that scientists could actually see the effect of learning on brain cells, and it found no damage.
But this was Reefer Madness II, and the prohibitionists were looking around for anything they could find to keep the marijuana legalization movement in check, so this study was widely used in anti-marijuana propaganda. It was recanted later.
(To this day, the radical anti-drug groups, like P.R.I.D.E. and Dr. Gabriel Nahas, still use it — In fact, America’s most popular drug education program, Drug Abuse Resistance Education, claims that marijuana can impair memory perception & judgement by destroying brain cells. When police and teachers read this and believe it, our job gets really tough, since it takes a long time to explain to children how Ms. Jones and Officer Bob were wrong.)
The truth is, no study has ever demonstrated cellular damage, stupidity, mental impairment, or insanity brought on specifically by marijuana use — even heavy marijuana use. This is not to say that it cannot be abused, however.